Middle-out Modeling of Multiscale Morphodynamics
نویسندگان
چکیده
How a fertilized egg develops into a multicellular organism remains one of the most challenging questions in biology. Novel techniques provides unprecedented high-resolution data on the spatiotemporal dynamics of the developing embryo. However, interpretation of these data requires both wet lab experiments and computational modeling (Oates et al., 2009). Here, we present a new modeling environment that is based on the following principles: Developmental systems (i) are multiscale systems, (ii) are morphodynamic, and (iii) require a middle-out modeling approach.
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